Positive regulation of synaptic vesicle endocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic vesicle endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METAP1, ZNF529, and ST3GAL3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METAP1 grouped by Positive regulation of synaptic vesicle endocytosis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	METAP1 →	+0.593	+0.413	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF529 →	+1.345	+0.173	.006	.004	3	4
LIVER	ST3GAL3 →	-1.026	-0.358	.002	.008	3	3
LIVER	RAB11FIP5 →	-1.230	-0.482	.002	.005	3	3
OVARY	TXNDC15 →	-0.897	-0.350	<.001	<.001	3	3
BREAST	VAMP1 →	+1.174	+0.770	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METAP1 by Positive regulation of synaptic vesicle endocytosis activity — LIVER

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