Positive regulation of synaptic vesicle endocytosis

Across TCGA cell cohorts, RNA activity of the Positive regulation of synaptic vesicle endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAS4, SLC37A2, and RNF181, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of synaptic vesicle endocytosis activity versus BCAS4 in SOFT_TISSUE (Pearson r = 0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	BCAS4 →	+1.703	+1.603	<.001	<.001	3	3
LARGE_INTESTINE	SLC37A2 →	+3.114	+1.721	<.001	<.001	3	3
SOFT_TISSUE	RNF181 →	+0.866	+1.603	.004	<.001	3	3
SOFT_TISSUE	CENPI →	+0.956	+1.603	.003	<.001	3	2
SOFT_TISSUE	RPL34 →	-0.670	-1.603	.004	<.001	3	2
SOFT_TISSUE	CTSC →	+5.366	+1.603	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900244 vs BCAS4 — SOFT_TISSUE

Explore this scatter interactively →