Regulation of phenotypic switching

Across TCGA cell cohorts, RNA activity of the Regulation of phenotypic switching pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNA6, KIF2C, and KLRC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFNA6 grouped by Regulation of phenotypic switching-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFNA6 →	+0.349	+0.445	.006	.003	3	4
BONE	KIF2C →	+0.218	+0.418	<.001	<.001	3	3
OVARY	KLRC4 →	-0.167	-0.271	.007	.003	3	3
BONE	RPUSD1 →	+0.218	+0.418	.003	<.001	3	3
OVARY	CD4 →	-0.134	-0.292	.001	.009	3	3
OVARY	ACSL6 →	+0.199	+0.352	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFNA6 by Regulation of phenotypic switching activity — CNS

Explore this box plot interactively →