Negative regulation of amyloid-beta clearance

Across TCGA patient cohorts, RNA activity of the Negative regulation of amyloid-beta clearance pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TNXB, JAK3_S20, and MYO9B_S2049, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid-beta clearance activity versus TNXB in CCRCC (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TNXB →	-0.467	-0.057	.003	<.001	2	5
GBM	JAK3_S20 →	-1.183	-0.186	<.001	.002	3	4
BRCA	MYO9B_S2049 →	-0.988	-0.105	.004	.004	3	4
COAD	MED28 →	+0.312	+0.037	<.001	.002	3	4
LUAD	KANK2_S375 →	-0.262	-0.038	.005	.007	3	4
LUAD	ARHGAP24_S415 →	-0.468	-0.040	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900222 vs TNXB — CCRCC

Explore this scatter interactively →