Negative regulation of amyloid-beta clearance

Across TCGA patient cohorts, RNA activity of the Negative regulation of amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA3, ADCY7, and ANO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid-beta clearance activity versus RASA3 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RASA3 →	+0.600	+0.639	.005	.006	3	5
OV	ADCY7 →	+0.643	+0.604	.003	.003	3	4
OV	ANO1 →	+1.202	+0.658	<.001	.001	3	4
BRCA	SHROOM4 →	+0.629	+0.509	<.001	.002	3	4
OV	DENND2C →	+0.475	+0.615	<.001	.001	3	4
LUAD	FAT4 →	+0.500	+0.475	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900222 vs RASA3 — UCEC

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