Negative regulation of amyloid-beta clearance

Across TCGA cell cohorts, RNA activity of the Negative regulation of amyloid-beta clearance pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FLNC, SSR4, and PCBP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of amyloid-beta clearance activity versus FLNC in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	FLNC →	+2.420	+0.240	<.001	<.001	3	4
CNS	SSR4 →	+1.010	+0.215	.005	.002	3	3
LUNG_SCLC	PCBP4 →	+1.630	+1.131	.003	.007	2	4
OVARY	CSNK1D →	+0.723	+0.325	.001	.002	3	3
OVARY	GXYLT2 →	+1.640	+0.252	.007	.006	2	4
BLOOD_Lymphoma	IL1R2 →	+4.157	+1.064	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900222 vs FLNC — UPPER_AERODIGESTIVE_TRACT

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