Positive regulation of protein localization to nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to nucleus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN20, OXCT2, and WDR37, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN20 grouped by Positive regulation of protein localization to nucleus-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ZSCAN20 →	+0.544	+0.150	.002	.001	3	4
KIDNEY	OXCT2 →	+0.568	+0.148	.003	.003	3	4
KIDNEY	WDR37 →	+0.588	+0.144	<.001	.001	2	5
PANCREAS	RNMT →	+0.647	+0.130	.001	.002	3	4
LARGE_INTESTINE	IDI1 →	-0.751	-0.095	.004	.004	3	4
BLOOD_Leukemia	ADORA2A →	+1.522	+0.163	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN20 by Positive regulation of protein localization to nucleus activity — KIDNEY

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