Positive regulation of protein localization to nucleus

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD51D, PMF1, and DUSP12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to nucleus activity versus RAD51D in LARGE_INTESTINE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAD51D →	+0.949	+0.158	.003	<.001	3	6
LIVER	PMF1 →	+0.787	+0.192	<.001	.002	3	5
OESOPHAGUS	DUSP12 →	+0.867	+0.209	.004	.002	3	5
LIVER	SLC5A6 →	+1.493	+0.166	.001	.002	3	5
OVARY	DNAJC17 →	+0.613	+0.177	<.001	.001	3	5
OVARY	MAD2L1 →	+0.911	+0.211	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900182 vs RAD51D — LARGE_INTESTINE

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