Negative regulation of protein localization to nucleus

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein localization to nucleus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCBD2, CYP4X1, and TRIM29, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein localization to nucleus activity versus PCBD2 in GBM (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCBD2 →	-0.380	-0.165	.002	.005	3	4
BRCA	CYP4X1 →	-1.439	-0.568	.004	.005	3	4
BRCA	TRIM29 →	+1.120	+0.692	<.001	<.001	3	4
BRCA	KRT16 →	+1.930	+0.641	<.001	.002	3	4
HNSC	SPRR1B →	+2.280	+0.488	.001	.004	3	4
LUAD	TTL →	+0.321	+0.714	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900181 vs PCBD2 — GBM

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