Negative regulation of protein localization to nucleus

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein localization to nucleus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAP47, TPP1, and H1-10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNAP47 grouped by Negative regulation of protein localization to nucleus-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SNAP47 →	+0.778	+0.360	.001	<.001	3	3
BLOOD_Leukemia	TPP1 →	-1.408	-0.239	.004	.009	2	4
BLOOD_Lymphoma	H1-10 →	+2.871	+0.277	.002	.004	3	3
BLOOD_Leukemia	CHP1 →	-0.957	-0.374	.002	<.001	3	3
BLOOD_Leukemia	MDFI →	+4.663	+0.352	<.001	<.001	2	3
BLOOD_Leukemia	IFI16 →	+2.920	+0.239	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNAP47 by Negative regulation of protein localization to nucleus activity — BLOOD_Leukemia

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