Regulation of protein localization to nucleus

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to nucleus pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNMT, SETX, and PHF12, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to nucleus activity versus RNMT in UVM (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	RNMT →	+1.277	+0.041	<.001	<.001	3	34
UVM	SETX →	+1.383	+0.039	<.001	<.001	3	34
DLBC	PHF12 →	+1.110	+0.051	<.001	<.001	3	34
ACC	ALMS1 →	+0.799	+0.038	<.001	<.001	3	34
THYM	ASH1L →	+1.446	+0.052	<.001	<.001	3	34
THYM	PRRC2C →	+1.148	+0.048	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900180 vs RNMT — UVM

Explore this scatter interactively →