Regulation of protein localization to nucleus

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNN2, FHL3, and ANXA6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to nucleus activity versus CNN2 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CNN2 →	+0.478	+0.024	<.001	<.001	3	7
BRCA	FHL3 →	+0.548	+0.024	<.001	.004	3	7
OV	ANXA6 →	+0.397	+0.047	<.001	<.001	3	7
OV	SEPTIN4 →	+0.601	+0.047	.001	.002	3	7
UCEC	SEPTIN4_S432 →	+0.588	+0.076	.001	.007	3	7
BRCA	TLN1 →	+0.362	+0.041	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900180 vs CNN2 — BRCA

Explore this scatter interactively →