Regulation of protein localization to nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to nucleus pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EHBP1, ADAMTS15, and PMF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to nucleus activity versus EHBP1 in OESOPHAGUS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EHBP1 →	+0.750	+0.147	.002	<.001	3	6
LIVER	ADAMTS15 →	-3.200	-0.253	<.001	.001	3	6
LIVER	PMF1 →	+0.681	+0.198	.007	.003	3	5
OESOPHAGUS	DUSP12 →	+0.835	+0.211	.004	<.001	2	5
KIDNEY	ARHGAP5 →	-0.979	-0.170	.007	.001	3	4
BLOOD_Myeloma	ZNF132 →	-1.215	-0.197	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900180 vs EHBP1 — OESOPHAGUS

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