Regulation of protein localization to nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to nucleus pathway is significantly associated with the protein abundance of multiple proteins, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LSM3, EEF1B2, and TRAPPC3, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to nucleus activity versus LSM3 in OVARY (Pearson r = 0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LSM3 →	+0.989	+0.216	.002	.002	3	16
LIVER	EEF1B2 →	+1.823	+0.276	.001	.001	3	15
URINARY_TRACT	TRAPPC3 →	+1.075	+0.242	<.001	<.001	3	15
URINARY_TRACT	PFDN1 →	+2.353	+0.252	<.001	.003	3	15
UPPER_AERODIGESTIVE_TRACT	UFM1 →	+1.755	+0.230	<.001	<.001	3	15
URINARY_TRACT	PFDN2 →	+2.440	+0.190	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900180 vs LSM3 — OVARY

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