"Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAN2A1, RPL18A, and RPS27L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus MAN2A1 in GBM (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAN2A1 →	-0.278	-0.035	.007	.004	3	5
GBM	RPL18A →	-0.287	-0.049	.002	.001	3	4
GBM	RPS27L →	-0.379	-0.038	.001	.002	3	4
LSCC	SLAIN2_S413 →	-0.739	-0.056	<.001	<.001	3	4
COAD	TOP2B →	+0.205	+0.030	<.001	.002	3	4
COAD	GALNT7 →	-0.395	-0.038	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900153 vs MAN2A1 — GBM

Explore this scatter interactively →