"Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NACAP10, SDHCP2, and UBE2V1P15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus NACAP10 in HNSC (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NACAP10 →	-0.732	-0.441	.001	.007	3	5
PDAC	SDHCP2 →	-0.285	-0.336	.005	.004	2	5
LSCC	UBE2V1P15 →	+0.421	+0.636	.006	.004	3	4
PDAC	SLC1A5 →	-0.466	-0.285	<.001	.006	3	3
PDAC	WDTC1 →	-0.263	-0.379	<.001	.002	3	3
GBM	POLL →	-0.303	-0.537	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900153 vs NACAP10 — HNSC

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