"Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC1, NLK, and SLIT2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PABPC1 grouped by "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PABPC1 →	-0.382	-0.371	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	NLK →	+0.098	+0.218	.007	.002	3	5
LUNG_SCLC	SLIT2 →	+0.206	+0.357	.007	.007	3	4
LARGE_INTESTINE	MMEL1 →	+0.222	+0.310	<.001	.009	3	4
PANCREAS	CSF2RA →	+0.374	+0.472	.002	<.001	3	4
BLOOD_Lymphoma	SUN2 →	+0.337	+0.529	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PABPC1 by "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity — CNS

Explore this box plot interactively →