"Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEIS1, ETV7, and PACSIN3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEIS1 grouped by "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MEIS1 →	+0.125	+0.298	.009	<.001	3	3
LARGE_INTESTINE	ETV7 →	-0.331	-0.191	<.001	.003	3	3
LARGE_INTESTINE	PACSIN3 →	-0.115	-0.099	.006	.008	3	3
BLOOD_Leukemia	UBTF →	+0.375	+0.224	.008	.002	3	3
BLOOD_Myeloma	ENTPD2 →	-0.452	-0.272	<.001	.005	3	3
BLOOD_Leukemia	AAK1 →	-0.208	-0.173	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEIS1 by "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity — STOMACH

Explore this box plot interactively →