"Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INHBA, SAMD4B, and KBTBD7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus INHBA in BONE (Pearson r = -0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	INHBA →	-4.140	-0.292	<.001	<.001	3	5
BLOOD_Myeloma	SAMD4B →	+0.894	+0.301	.005	<.001	3	4
SOFT_TISSUE	KBTBD7 →	+1.214	+0.347	.002	<.001	2	5
BLOOD_Leukemia	TPST1 →	-1.137	-0.127	<.001	.003	3	4
SOFT_TISSUE	DIXDC1 →	+2.569	+0.455	.004	<.001	3	3
SOFT_TISSUE	SLC25A27 →	-1.782	-0.398	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900153 vs INHBA — BONE

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