"Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL26, GALNT7, and COPB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus RPL26 in HNSC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPL26 →	-0.357	-0.117	.002	.002	3	5
GBM	GALNT7 →	-0.362	-0.052	<.001	<.001	3	5
GBM	COPB1 →	-0.124	-0.051	<.001	<.001	3	5
UCEC	ARFIP1_S39 →	-0.419	-0.084	<.001	.001	3	5
GBM	MAN2A1 →	-0.412	-0.048	<.001	<.001	3	5
UCEC	SEC16A →	-0.200	-0.079	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900151 vs RPL26 — HNSC

Explore this scatter interactively →