"Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA patient cohorts, RNA activity of the "Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS1, MORN4, and CPEB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus DHRS1 in LSCC (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DHRS1 →	-0.448	-0.178	<.001	<.001	3	4
LSCC	MORN4 →	-0.328	-0.094	.003	.006	3	4
LUAD	CPEB3 →	-0.260	-0.122	.001	.008	3	4
BRCA	RABGGTA →	-0.344	-0.279	.002	.005	3	3
BRCA	ORMDL2 →	-0.277	-0.361	.008	.007	3	3
HNSC	IGF2BP1 →	+1.790	+0.180	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900151 vs DHRS1 — LSCC

Explore this scatter interactively →