"Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"

Across TCGA cell cohorts, RNA activity of the "Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP29, DOK7, and CENPV, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay" activity versus ARHGAP29 in LIVER (Pearson r = -0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ARHGAP29 →	-2.310	-0.269	.002	<.001	3	6
CNS	DOK7 →	-1.632	-0.148	.001	.004	3	6
BONE	CENPV →	+2.592	+0.279	.006	<.001	3	6
OVARY	METTL16 →	+0.916	+0.277	.005	<.001	3	6
OVARY	RTN4IP1 →	+1.543	+0.265	<.001	<.001	3	6
OVARY	RRS1 →	+0.686	+0.171	.002	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900151 vs ARHGAP29 — LIVER

Explore this scatter interactively →