Across TCGA patient cohorts, RNA activity of the Obsolete regulation of nodal signaling pathway involved in determination of left/right asymmetry pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are JCAD, AFAP1L2_T541, and ADD1_S481, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	JCAD →	-0.187	-0.098	<.001	<.001	3	5
CCRCC	AFAP1L2_T541 →	-0.421	-0.073	<.001	.001	3	5
GBM	ADD1_S481 →	-0.582	-0.101	<.001	<.001	3	4
GBM	AKAP12_S1512 →	-0.526	-0.043	.004	.008	3	4
LUAD	IFIT3_S203 →	-1.334	-0.156	<.001	<.001	3	4
HNSC	VPS4B →	+0.213	+0.077	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration

Obsolete regulation of nodal signaling pathway involved in determination of left/right asymmetry survival · tumor vs normal · full GO:1900145 profile