Regulation of receptor binding

Across TCGA patient cohorts, RNA activity of the Regulation of receptor binding pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CAST_S575, MAPK9, and MAP3K5_S1033, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of receptor binding activity versus CAST_S575 in HNSC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CAST_S575 →	+0.559	+0.079	<.001	.002	3	5
LSCC	MAPK9 →	+0.202	+0.090	<.001	<.001	3	5
LSCC	MAP3K5_S1033 →	+0.537	+0.075	<.001	<.001	3	4
GBM	ARPC1B →	+0.401	+0.104	.001	<.001	3	4
GBM	TNKS1BP1_S429 →	+0.400	+0.081	<.001	<.001	3	4
GBM	TRAF1 →	+0.384	+0.064	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900120 vs CAST_S575 — HNSC

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