Regulation of receptor binding

Across TCGA cell cohorts, RNA activity of the Regulation of receptor binding pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GMNN, TEX30, and LGALSL, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GMNN grouped by Regulation of receptor binding-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GMNN →	+0.625	+0.947	.008	.009	3	3
SKIN	TEX30 →	+0.701	+0.960	<.001	.003	3	3
LIVER	LGALSL →	+0.955	+0.394	.006	.007	3	3
BLOOD_Leukemia	ILK →	-1.031	-0.245	<.001	<.001	3	3
BONE	LNX2 →	-0.543	-0.231	.001	.003	3	2
BONE	NME7 →	-0.732	-0.225	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GMNN by Regulation of receptor binding activity — SKIN

Explore this box plot interactively →