Negative regulation of execution phase of apoptosis

Across TCGA patient cohorts, RNA activity of the Negative regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIPA1L2, FAM124B, and SCN1A, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of execution phase of apoptosis activity versus SIPA1L2 in LUAD (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SIPA1L2 →	-0.776	-0.489	.001	.005	3	2
LUAD	FAM124B →	-0.407	-0.542	.007	.005	3	2
LUAD	SCN1A →	-0.655	-0.646	<.001	<.001	3	2
LUAD	ADAT3 →	-0.266	-0.480	.001	<.001	3	2
LUAD	RPL21P16 →	+0.457	+0.559	.001	.003	3	2
LUAD	RNU7-55P →	-0.759	-0.520	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900118 vs SIPA1L2 — LUAD

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