Negative regulation of execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Negative regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS13, FANCF, and ZNF516, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHRS13 grouped by Negative regulation of execution phase of apoptosis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DHRS13 →	+1.495	+1.730	.009	.009	3	4
BLOOD_Lymphoma	FANCF →	+1.454	+2.264	.003	<.001	3	4
BLOOD_Leukemia	ZNF516 →	-1.809	-0.281	.003	.004	3	4
BLOOD_Leukemia	CD200R1 →	+2.357	+0.267	.001	.003	3	4
BLOOD_Leukemia	SCN9A →	+1.284	+0.267	<.001	<.001	3	4
BLOOD_Leukemia	OSBPL3 →	+1.297	+0.299	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHRS13 by Negative regulation of execution phase of apoptosis activity — BLOOD_Lymphoma

Explore this box plot interactively →