Regulation of execution phase of apoptosis

Across TCGA patient cohorts, RNA activity of the Regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNK17, CDO1, and LINC01936, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of execution phase of apoptosis activity versus KCNK17 in HNSC (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KCNK17 →	+0.333	+0.602	.004	<.001	2	5
HNSC	CDO1 →	+1.043	+0.717	<.001	<.001	3	4
CCRCC	LINC01936 →	+0.728	+0.655	<.001	<.001	3	4
UCEC	IGKV1D-8 →	-0.748	-0.783	.008	.006	3	4
BRCA	RSPO4 →	+0.472	+0.510	.005	<.001	3	4
LSCC	GATA6-AS1 →	+0.219	+0.641	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900117 vs KCNK17 — HNSC

Explore this scatter interactively →