Regulation of execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF168, ZMAT3, and PSMD10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF168 grouped by Regulation of execution phase of apoptosis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RNF168 →	+0.395	+1.283	.005	.004	3	4
CNS	ZMAT3 →	-0.995	-1.286	.005	<.001	3	4
BLOOD_Leukemia	PSMD10 →	+0.669	+1.035	.006	.006	3	4
LUNG_NSCLC_LUAD	TMEM245 →	+0.491	+0.596	.008	.007	2	5
SKIN	PON2 →	-0.686	-1.203	.004	<.001	3	3
SKIN	TOR1AIP1 →	-0.510	-0.858	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF168 by Regulation of execution phase of apoptosis activity — SKIN

Explore this box plot interactively →