Regulation of execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Regulation of execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCP2, PSTPIP2, and PYGL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of execution phase of apoptosis activity versus SCP2 in STOMACH (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SCP2 →	-1.044	-0.168	.001	.005	3	5
KIDNEY	PSTPIP2 →	+2.314	+0.317	.006	.009	3	5
LARGE_INTESTINE	PYGL →	+1.955	+0.209	.004	.006	3	5
LARGE_INTESTINE	SUPT20H →	-0.739	-0.303	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	YAE1 →	-1.134	-0.297	<.001	.002	3	5
OVARY	TAF15 →	-0.863	-0.185	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900117 vs SCP2 — STOMACH

Explore this scatter interactively →