Regulation of nodal signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of nodal signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLEC11A, FHL2, and FBN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nodal signaling pathway activity versus CLEC11A in BRCA (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLEC11A →	+0.973	+0.075	<.001	<.001	3	6
LSCC	FHL2 →	+0.648	+0.089	<.001	<.001	3	6
LSCC	FBN1 →	+0.371	+0.076	<.001	<.001	3	6
BRCA	SERPINF1 →	+0.791	+0.068	<.001	<.001	3	5
BRCA	SH3BP4 →	+0.541	+0.076	<.001	<.001	3	5
BRCA	CD276 →	+0.403	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900107 vs CLEC11A — BRCA

Explore this scatter interactively →