Regulation of nodal signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of nodal signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRXL2B, UCHL5, and ZNF439, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRXL2B grouped by Regulation of nodal signaling pathway-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRXL2B →	+2.025	+1.948	.003	.004	2	4
LUNG_SCLC	UCHL5 →	+0.910	+0.428	<.001	.002	3	3
LUNG_SCLC	ZNF439 →	-1.759	-0.406	.009	.005	3	3
OESOPHAGUS	ABHD15 →	+1.254	+0.241	.003	<.001	2	4
STOMACH	LRBA →	+1.461	+0.291	.004	<.001	3	3
BREAST	COX15 →	+0.572	+0.583	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRXL2B by Regulation of nodal signaling pathway activity — BLOOD_Lymphoma

Explore this box plot interactively →