Regulation of endoplasmic reticulum unfolded protein response

Across TCGA cell cohorts, RNA activity of the Regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSC22D1, SLC25A1, and TMEM150A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSC22D1 grouped by Regulation of endoplasmic reticulum unfolded protein response-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TSC22D1 →	-1.372	-0.393	.006	.009	3	4
PANCREAS	SLC25A1 →	-0.793	-0.206	<.001	.001	3	4
BREAST	TMEM150A →	-0.775	-0.194	.002	.001	3	4
PANCREAS	OVOL2 →	+1.273	+0.253	.006	.002	3	4
PANCREAS	RASA3 →	-1.527	-0.287	.003	.001	3	4
LARGE_INTESTINE	SGCB →	+1.087	+0.232	.005	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSC22D1 by Regulation of endoplasmic reticulum unfolded protein response activity — URINARY_TRACT

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