Regulation of endoplasmic reticulum unfolded protein response

Across TCGA cell cohorts, RNA activity of the Regulation of endoplasmic reticulum unfolded protein response pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN1, SDC4, and CHCHD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of endoplasmic reticulum unfolded protein response activity versus TSPAN1 in BREAST (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TSPAN1 →	+3.461	+0.275	<.001	<.001	3	6
CNS	SDC4 →	+1.582	+0.167	<.001	.001	3	5
SKIN	CHCHD3 →	-0.956	-0.306	<.001	<.001	3	5
LUNG_NSCLC_LUSC	TNFRSF14 →	+1.829	+0.222	.008	.005	3	5
STOMACH	GIGYF1 →	-0.901	-0.265	.005	.001	3	5
CNS	SPANXB1 →	+3.536	+0.225	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900101 vs TSPAN1 — BREAST

Explore this scatter interactively →