Negative regulation of ceramide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of ceramide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLPB, EVA1C, and CHIT1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ceramide biosynthetic process activity versus CLPB in LSCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLPB →	-0.496	-0.635	.003	.002	3	3
GBM	EVA1C →	+0.587	+0.216	.004	<.001	3	3
LUAD	CHIT1 →	+0.823	+0.394	.005	.002	3	3
PDAC	NPHS1 →	-0.643	-0.452	.001	.003	3	2
PDAC	CTRC →	-3.646	-0.360	<.001	.007	3	2
PDAC	ONECUT1 →	-0.848	-0.321	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900060 vs CLPB — LSCC

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