Negative regulation of protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein K63-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FBP2, DSTNP2, and ZNF252P-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein K63-linked ubiquitination activity versus FBP2 in GBM (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FBP2 →	-0.059	-0.335	.006	.005	3	3
COAD	DSTNP2 →	-0.393	-0.255	.003	.006	3	3
LUAD	ZNF252P-AS1 →	-0.206	-0.304	.007	.007	3	3
PDAC	CLDN14 →	+0.394	+0.311	<.001	.003	3	2
GBM	RPL22P16 →	-0.283	-0.277	.008	.008	3	2
COAD	GLRA2 →	-1.052	-0.267	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900045 vs FBP2 — GBM

Explore this scatter interactively →