Negative regulation of protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein K63-linked ubiquitination pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP10_S431, FTSJ1_S271, and TOB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein K63-linked ubiquitination activity versus PARP10_S431 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PARP10_S431 →	+0.635	+0.244	<.001	.002	2	5
OV	FTSJ1_S271 →	+1.432	+1.601	<.001	<.001	3	3
UCEC	TOB2 →	-0.431	-0.742	<.001	.001	3	3
OV	REXO1_S287 →	-2.331	-1.644	.003	<.001	3	3
BRCA	TLK2_S111 →	+0.947	+0.315	<.001	<.001	2	4
UCEC	TOX_S220 →	-1.520	-1.757	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900045 vs PARP10_S431 — LSCC

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