Negative regulation of cellular response to hypoxia

Across TCGA cell cohorts, RNA activity of the Negative regulation of cellular response to hypoxia pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP4R2, NUP155, and ANKH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP4R2 grouped by Negative regulation of cellular response to hypoxia-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PPP4R2 →	-0.713	-1.105	<.001	<.001	3	5
BREAST	NUP155 →	+0.633	+0.645	.005	.003	3	3
BONE	ANKH →	+2.870	+1.423	<.001	.002	2	4
BLOOD_Leukemia	RASGRP4 →	-2.209	-0.700	<.001	.006	3	3
BLOOD_Leukemia	HOXB2 →	-2.012	-0.729	.007	.004	3	3
BLOOD_Leukemia	EPN2 →	-1.237	-0.916	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP4R2 by Negative regulation of cellular response to hypoxia activity — KIDNEY

Explore this box plot interactively →