Regulation of cellular response to hypoxia

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to hypoxia pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRAP2, TNFSF8, and MS4A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to hypoxia activity versus GRAP2 in LSCC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GRAP2 →	-0.530	-0.144	.001	.003	3	5
LSCC	TNFSF8 →	-0.447	-0.123	.004	.005	3	5
LSCC	MS4A1 →	-1.295	-0.207	<.001	<.001	3	5
LSCC	PGAM1 →	+0.589	+0.202	<.001	<.001	3	5
LUAD	ERO1A →	+0.910	+0.223	<.001	<.001	3	5
LSCC	NDRG1 →	+1.087	+0.136	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900037 vs GRAP2 — LSCC

Explore this scatter interactively →