Regulation of cellular response to heat

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to heat pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DGAT1, TMEM86A, and IRGM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DGAT1 grouped by Regulation of cellular response to heat-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DGAT1 →	+0.712	+0.935	.003	.001	3	4
BLOOD_Leukemia	TMEM86A →	+0.454	+0.805	.001	.006	3	3
BLOOD_Leukemia	IRGM →	-1.267	-1.126	<.001	.001	3	3
LUNG_NSCLC_LUAD	SUPT3H →	-0.900	-0.970	.001	.001	3	3
BREAST	ZNF474 →	-0.153	-0.618	.005	.001	3	3
BREAST	TLCD3A →	-1.264	-0.671	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DGAT1 by Regulation of cellular response to heat activity — LUNG_SCLC

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