Regulation of cellular response to heat

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to heat pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAP1, TTLL12, and HSP90AB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to heat activity versus TRAP1 in CNS (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TRAP1 →	+0.943	+1.250	.005	.003	2	7
STOMACH	TTLL12 →	+0.931	+1.587	.006	<.001	3	5
PANCREAS	HSP90AB1 →	+1.161	+1.832	.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PPP2R5D →	+0.747	+1.316	.001	<.001	3	5
LUNG_SCLC	SLC35F2 →	+2.239	+1.190	.001	.003	3	5
URINARY_TRACT	POLR3G →	+2.278	+1.600	.002	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900034 vs TRAP1 — CNS

Explore this scatter interactively →