Positive regulation of ruffle assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RFLNB, COBL, and ADAM19, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ruffle assembly activity versus RFLNB in CCRCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RFLNB →	-0.737	-0.645	.001	.006	3	5
GBM	COBL →	+0.799	+0.463	.005	.008	2	6
BRCA	ADAM19 →	-0.623	-0.735	.002	.005	3	5
LSCC	MEX3A →	-0.953	-0.513	<.001	.001	3	5
HNSC	NEMP1 →	-0.597	-0.451	<.001	.004	3	5
HNSC	ARMCX5-GPRASP2 →	-0.382	-0.469	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900029 vs RFLNB — CCRCC

Explore this scatter interactively →