Positive regulation of ruffle assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCHP, MYH10, and FARS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCHP grouped by Positive regulation of ruffle assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCHP →	-0.897	-0.675	<.001	.007	3	5
BLOOD_Leukemia	MYH10 →	-2.817	-0.552	<.001	.006	3	4
BLOOD_Leukemia	FARS2 →	-0.443	-0.565	.005	.005	3	4
PANCREAS	WDR4 →	-0.957	-0.371	<.001	<.001	3	3
CNS	PICK1 →	-0.985	-0.575	.007	.006	3	3
BLOOD_Leukemia	TIMM44 →	-0.818	-0.352	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCHP by Positive regulation of ruffle assembly activity — BLOOD_Leukemia

Explore this box plot interactively →