Negative regulation of ruffle assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of ruffle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UTP4, MPHOSPH10, and SAMHD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ruffle assembly activity versus UTP4 in LSCC (Pearson r = -0.50).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UTP4 →	-0.295	-0.065	<.001	<.001	3	8
LSCC	MPHOSPH10 →	-0.366	-0.077	<.001	<.001	3	8
HNSC	SAMHD1 →	+0.502	+0.069	<.001	.005	3	7
GBM	SASH3 →	+0.429	+0.105	<.001	<.001	3	7
LUAD	SEPTIN4_S117 →	+0.838	+0.088	<.001	<.001	3	7
LUAD	ATXN2L_S424 →	-0.611	-0.067	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900028 vs UTP4 — LSCC

Explore this scatter interactively →