Negative regulation of ruffle assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16B, ARHGEF6, and PRKCB, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ruffle assembly activity versus PPP1R16B in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R16B →	+1.008	+0.694	<.001	.001	3	6
BRCA	ARHGEF6 →	+0.892	+0.424	<.001	<.001	3	6
HNSC	PRKCB →	+0.769	+0.378	<.001	.004	3	6
LSCC	CELF2 →	+0.540	+0.350	<.001	<.001	3	6
UCEC	ABCA8 →	+0.809	+0.418	.001	.004	3	5
UCEC	CD226 →	+0.623	+0.710	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900028 vs PPP1R16B — UCEC

Explore this scatter interactively →