Negative regulation of ruffle assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of ruffle assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP91-CNTF, RNF130, and PACSIN2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFP91-CNTF grouped by Negative regulation of ruffle assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZFP91-CNTF →	+0.126	+0.269	<.001	.007	3	4
SKIN	RNF130 →	+0.185	+0.198	.006	.005	3	3
URINARY_TRACT	PACSIN2 →	-0.245	-0.475	.005	.006	3	3
SKIN	ZNF93 →	+0.212	+0.277	.007	<.001	3	3
CNS	ALPP →	+0.195	+0.417	.001	.002	3	3
OVARY	GTF2B →	-0.345	-0.421	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFP91-CNTF by Negative regulation of ruffle assembly activity — OESOPHAGUS

Explore this box plot interactively →