Negative regulation of ruffle assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT4, ZNF90, and EVI5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ruffle assembly activity versus ACOT4 in LUNG_SCLC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ACOT4 →	+1.007	+0.261	.002	.002	3	3
LUNG_SCLC	ZNF90 →	+1.707	+0.236	.002	.004	3	3
LUNG_SCLC	EVI5 →	-1.189	-0.266	.001	.005	3	3
OVARY	ANAPC16 →	+0.923	+0.270	.002	.002	3	3
OVARY	RTKN2 →	+1.048	+0.341	.006	.003	3	3
OVARY	SEC62 →	+1.111	+0.394	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900028 vs ACOT4 — LUNG_SCLC

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