Regulation of ruffle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of ruffle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MKI67_S357, NAA10_S186, and RPL10A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ruffle assembly activity versus MKI67_S357 in LUAD (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MKI67_S357 →	-1.319	-0.036	<.001	<.001	3	7
LSCC	NAA10_S186 →	-0.497	-0.053	<.001	<.001	3	7
OV	RPL10A →	-0.188	-0.029	.004	.002	3	7
LSCC	RFC1_S368 →	-0.737	-0.049	<.001	.001	3	6
GBM	RRP36_S73 →	-0.857	-0.077	<.001	<.001	3	6
GBM	RRP9 →	-0.381	-0.065	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900027 vs MKI67_S357 — LUAD

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