Regulation of ruffle assembly

Across TCGA patient cohorts, RNA activity of the Regulation of ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIF1, CBX2, and HELLS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ruffle assembly activity versus PIF1 in BRCA (Pearson r = -0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PIF1 →	-0.872	-0.259	<.001	<.001	3	5
OV	CBX2 →	-0.735	-0.102	.004	.008	3	5
HNSC	HELLS →	-0.508	-0.158	.001	.001	3	5
LSCC	RCOR2 →	-1.042	-0.369	.002	.009	3	5
BRCA	AURKB →	-0.946	-0.257	<.001	.006	3	5
BRCA	GTSE1 →	-0.797	-0.241	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1900027 vs PIF1 — BRCA

Explore this scatter interactively →