Regulation of ruffle assembly

Across TCGA cell cohorts, RNA activity of the Regulation of ruffle assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRPF38A, DNAJC11, and FBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRPF38A grouped by Regulation of ruffle assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRPF38A →	-0.799	-1.127	<.001	.006	3	5
BLOOD_Leukemia	DNAJC11 →	-0.741	-0.871	<.001	<.001	3	5
KIDNEY	FBP1 →	-0.116	-0.659	.001	.001	3	4
OESOPHAGUS	TCF20 →	-0.624	-0.710	.001	.006	3	4
BREAST	SCLY →	-0.722	-0.527	.001	.006	2	5
BLOOD_Leukemia	SETD1B →	-0.567	-0.836	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRPF38A by Regulation of ruffle assembly activity — BLOOD_Leukemia

Explore this box plot interactively →